Mexican meatloaf is a flavorful twist on the classic comfort food, blending traditional meatloaf ingredients with bold Mexican spices and ingredients for a dish that’s both familiar and exciting. It’s hearty, satisfying, and ideal for weeknight dinners, family meals, or gatherings where you want to serve something comforting with a bit of a kick.
Instead of relying solely on breadcrumbs and ketchup like in the traditional version, Mexican meatloaf introduces elements like cumin, chili powder, and smoked paprika to infuse the meat with warm, spicy depth. Chopped onions, garlic, and green chilies add texture and a punch of flavor, while corn, black beans, or diced tomatoes can be mixed in for a bit of moisture and variety.
Cheese is another welcome addition. Shredded cheddar or Monterey Jack folded into the meat mixture creates gooey pockets of richness, while a thin layer of cheese melted on top during the final minutes of baking gives the loaf a golden, bubbly finish. Some recipes even feature a spicy salsa glaze in place of traditional ketchup, which caramelizes beautifully in the oven and adds tang and heat.
Ground beef is the most common choice, but turkey or a blend of beef and pork works well, too. Eggs and breadcrumbs (or crushed tortilla chips for extra flavor) help bind everything together and give the loaf structure.
One of the best things about Mexican meatloaf is how versatile it is. Serve it with a side of Mexican rice, a fresh green salad, or roasted vegetables. Leftovers are excellent sliced into sandwiches, tucked into tortillas for quick tacos, or crumbled into scrambled eggs.
Whether you’re trying to liven up a weekday dinner or want something cozy but different, Mexican meatloaf delivers. It’s everything you love about the original, with an irresistible twist that adds color, spice, and personality to your plate.

Ingredients
- 1.5 lb ground beef
- 1 cup bread crumbs
- 1/2 cup salsa
- 1/2 cup shredded Mexican cheese blend
- 1/4 cup cilantro chopped fresh
- 1/4 cup red onion diced
- 1 egg beaten
- 1 tsp chili powder
- 1/2 tsp cumin
- 1/2 tsp paprika
- 1/2 tsp garlic powder
- 1/2 tsp salt
- 1/4 tsp black pepper
- 1/4 cup ketchup
- 1 tbsp brown sugar
- 1 tbsp Worcestershire sauce
Instructions
- Preheat the oven to 350°F (175°C).
- In a large bowl, combine the ground beef, bread crumbs, salsa, shredded cheese, cilantro, red onion, egg, chili powder, cumin, paprika, garlic powder, salt, and black pepper. Mix until well combined.
- Transfer the mixture to a greased loaf pan and press it down evenly.
- In a small bowl, whisk together the ketchup, brown sugar, and Worcestershire sauce. Spread the mixture over the meatloaf.
- Bake in the preheated oven for 1 hour, or until the internal temperature reaches 160°F (71°C).
- Remove from the oven and let rest for 5 minutes before slicing.
- Serve the Mexican Meatloaf with additional salsa, if desired.
- Enjoy!
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Why is there ketchup on meatloaf? Just use BBQ sauce. Smh.
Yuck! Not what I expected. Meatloaf should not have salsa in it. I wouldn’t serve this to guests.
Nah, I like my meatloaf plain. Salsa in meatloaf just don’t make sense, not for me. Stick to the classics!
I actually think the salsa adds a unique flavor! It’s not traditional, but it’s different. Give it a try before writing it off!
I wasn’t sure about the salsa in meatloaf, but it turned out pretty good. I might try adding some corn next time.
Salsa in meatloaf? Really? That don’t sound right. I doubt it would be good. 🙄
Adding corn sounds interesting! I usually just stick to the classical flavor but I might just give that a try too.
This recipe is super easy and quick to make! I added a little extra cheese and it was a hit with my fam. 4 stars!
Just made this for dinner, and my whole family loved it! Definitely a keeper!
It was ok, but I think I put too much cumin in. My kids didn’t like it. Next time, I’ll hold back on the spices.
I dont know, but my kids love spices. Maybe they just prefer bland food? 🤷♂️
Totally understand! Cumin can be really strong. I usually start with less and add more if needed. Hope it works out better for you next time!
This meatloaf is amazing! The salsa adds such a nice flavor. I’ll definitely make it again!
Too much cheese for my taste, but my kids loved it. They gonna make me do this again.
Meh, don’t get the hype. It’s just meat with some stuff on it.
I totally disagree! This meatloaf looks so flavorful with all those spices. It’s not just meat, it’s a fiesta on a plate! 🌮
This meatloaf is just okay, taste kinda different from what I’m used to.
Meatloaf?! More like meatloaf of my dreams! Yummy, spicy, and satisfying. Coming back for more! 5 stars.
Yum! I love spicy and this hit the spot! Will share the recipe!
Just another meatloaf. Nothing special here. Sorry but I expected more flavor.
Can you use turkey instead of beef? My wife loves turkey and I’m just curious. Thanks! 3 stars for now.
Simple and delicious! I added some jalapeños for a kick, turned out great!
Ok but how come the ketchup don’t look flashy in the picture? Just throwing it out there. 🤔 3 stars.
Yum! The best meatloaf I’ve ever tasted! Gonna make this every week! 🥳
Great twist! I used ground turkey instead, and it still turned out good. Thanks!
I didn’t have salsa, so I used tomato sauce instead. It was a total disaster!
Meatloaf? I thought this was a taco recipe. 🤷♂️
Easy to make but I think I added too much chili powder. 🔥 Next time I’ll tone it down.
This was delicious! The flavors are amazing. My family loved it! 😍
I’m so glad to hear you loved it! It’s a family favorite around here too! 😋
What even is this?? Meatloaf with salsa? Sounds weird. I stick to the classic recipe. 🤷♂️
I think it sounds kinda good! Mixing cultures like that can be fun. Give it a shot! 🌮🍽️
This is the BEST meatloaf I have ever made! The salsa adds such a great kick. Going to make this every week!
My meatloaf fell apart when I sliced it. Must’ve mixed it too much?
So. Delicious. Can’t believe how easy this is! Will make again!
Easy recipe! My kids loved it and that’s saying something! Will be trying it again for sure!
I’m allergic to cilantro, can I use parsley instead? Hope it still tastes good.
Yes, parsley should work fine! Just remember it has a different flavor than cilantro, but it will still taste good. Enjoy your meatloaf!
Just okay. Nothing special, honestly. I prefer plain meatloaf.
I dunno about using salsa in meatloaf. That seems kinda weird. My grandma never did that.
I tried it and it burnt. Not sure if my oven is broken or what. Not good! 1 star.
Maybe your oven temp is off? Try using an oven thermometer next time. The recipe sounds great otherwise!
This is the BEST meatloaf I’ve ever made! So flavorful and moist. I’m making it again next week!
My husband loved this! He said it was a keeper. I used ground turkey instead of beef, still great!
I forgot the egg and it was a total mess 🤦. Maybe my fault lol.
I followed the instructions but my meatloaf fell apart when I sliced it. Maybe I should have added more egg or somethin?
It’s just meatloaf with a little Mexican twist. I prefer classic recipes, but it wasn’t terrible.
Wow, this looks amazing! Can’t wait to try it out this weekend. My family loves meatloaf!
This recipe is amazing! My family loved it! The salsa adds such a great flavor.
Meatloaf? More like meat brick! Never again.
I was skeptical at first, but wow! This turned out better than I expected. It’s spicy but not too much.
I’m glad to hear it turned out well! I was worried the spice might be too much for my kids, but now I think I’ll give it a try.
Tried this today, but I used turkey instead of beef. Still good! 👍
Absolutely loved this! The combination of Mexican flavors took meatloaf to a whole new level. 5 stars!
I’m glad you loved it! Mexican flavors really do make everything better, don’t they? 5 stars for sure! 🌟
I don’t know about this… meatloaf with salsa? Seems weird. I might stick to traditional recipes. 2 stars.
I totally get that! Salsa in meatloaf does sound unusual. But trust me, it actually adds a unique flavor to it! Give it a chance! 😊
Nah, man. Salsa is for chips, not meatloaf! Stick to the classics. 1 star for this idea!
Meatloaf??? With salsa??? I dunno, sounds weird. I like mine plain. Just missed the mark for me.
This meatloaf is AMAZING! Super flavorful and easy to make!
Yummy!!! ❤️❤️
This looks amazing! Can’t wait to try it. 😍
Yummy! I added black beans and corn too. Was a hit! 🥳
This looks complicated but I’m going to try it since I have all the ingredients at hand!
So good! I’m going to tell all my friends. The cheese really makes it special!
I don’t like cilantro. Made it without it and it was still good.
I don’t think meatloaf should ever be Mexican. Sounds weird, but okay.
Nah, I can’t agree with this. Meatloaf is meant to be basic, not all this fancy stuff. Keep it classic!
I actually think that sounds kind of cool! A spicy meatloaf could be really good! Let’s give it a shot.
I think meatloaf should be more classic. I don’t get why people are messing with it.
Hate it. Too much cheese. Slimey texture. Never again.
I actually love the cheesy texture! It adds so much flavor. Maybe try less cheese next time? 😂
I was skeptical at first, but it turned out pretty good! The flavors were nice, but I think it needed more seasoning, maybe some hot sauce?