In a large bowl, whisk together the flour, sugar, baking powder, baking soda, salt, and pumpkin pie spice.
In another bowl, mix together the buttermilk, pumpkin puree, egg, melted butter, and vanilla extract.
Pour the wet ingredients into the dry ingredients, stirring until just combined. Do not overmix.
Heat a non-stick skillet or griddle over medium heat and lightly grease it with butter or cooking spray.
Pour 1/4 cup of batter onto the skillet for each pancake. Cook until bubbles form on the surface and the edges look set, then flip and cook until golden brown on the other side.
Serve warm with maple syrup, whipped cream, and a sprinkle of cinnamon if desired.