In a medium saucepan, thoroughly whisk together the ketchup, apple cider vinegar, dark brown sugar, hot sauce, Worcestershire sauce, and molasses until the sugar is fully dissolved.
Stir in the chili powder, cayenne pepper, smoked paprika, garlic powder, black pepper, and salt.
Place the saucepan over medium-low heat and bring the fiery mixture to a gentle simmer, stirring frequently so the sugars do not stick to the bottom.
Once simmering, turn the heat to its lowest setting. Let the sauce bubble gently for 10 to 15 minutes to allow the intense spices to meld with the sweet and tangy base.
Remove the pan from the heat. Let the sauce cool entirely at room temperature before transferring it to a glass jar. Store in the refrigerator for up to 2 weeks.